The vessel, in service for nearly 35 years, will be decommissioned on March 31 in a ceremony in San Diego, Calif., the Navy said.
"The last general-purpose amphibious assault ship of the Tarawa class, Peleliu's decommissioning marks the end of a career comprising multiple deployments to U.S. 7th and 5th Fleet, humanitarian efforts and peacekeeping missions," the Navy said.
"Capable of launching a coordinated air and sea attack from one platform, Peleliu has conducted 17 deployments, 178,051 flight operations, served 57,983 personnel and steamed approximately 1,011,946 nautical miles since being commissioned May 3, 1980."
The ship took part in Operation Enduring Freedom (Afghanistan) and Operation Iraqi Freedom. It is 820 feet long, 106.6 feet in the beam and a speed of 24 knots.
The Navy said that after decommissioning the ship will be towed to Pearl Harbor in Hawaii and join the Navy's reserve fleet of vessels.
The USS Peleliu (LHA-5) is a Tarawa-class amphibious assault ship of the United States Navy.